Flexeril Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

While 10 mg is a common dosage, cyclobenzaprine can often be effective in lower doses. It’s also recommended for night-time use due to its drowsiness effects. With a half-life ranging from 8 to 37 hours for immediate-release and between 32 and 33 hours for extended-release, cyclobenzaprine can potentially stay in the body for up to three days.

  • CYCLOBENZAPRINE (sye kloe BEN za preen) treats muscle spasms.
  • It was also designed to identify variables that might be useful markers of drug effects.
  • It accumulates and, if dosed three times a day, can reach steady-state within 3-4 days.
  • This product may contain inactive ingredients, which can cause allergic reactions or other problems.

Cyclobenzaprine is a muscle relaxer used to treat muscle spasms and acute muscle pain. It’s not intended for long-term use or to treat chronic pain. Cyclobenzaprine and muscle relaxers like it are usually prescribed following an injury, car accident, or another minor incident that causes muscle spasms and other temporary muscle conditions. Clinicians should monitor for signs and symptoms of serotonin syndrome if the patient is taking other serotonergic drugs.


When certain drugs are used with cyclobenzaprine, they may cause more severe side effects such as increased drowsiness or sedation. A person should ask their doctor whether it is safe to combine another medication with cyclobenzaprine and take care not to operate any machinery while taking it. The efficacy of FLEXERIL 5 mg was demonstrated in two seven-day, double-blind, controlled clinical trials enrolling 1405 patients. One study compared FLEXERIL 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo. Primary endpoints for both trials were determined by patient-generated data and included global impression of change, medication helpfulness, and relief from starting backache.

Due to Flexeril’s half-life, it can stay detectable for up to three to eight days for people who took higher doses. In contrast, if a person of average weight takes the regular recommended dosage, the drug will be undetectable in their urine four days after the previous dose. Extreme stress can cause increased muscle tension and worsen your current pain or discomfort.

Doing so increases their risk of developing anticholinergic toxidrome and overdosing on the drug. Laboratory data were summarized, and mean change was presented for each numeric variable. Laboratory data were classified as low, normal, or high and out-of-range values were flagged. The treatment arms were compared with respect to mean change using the 2-sample t test. Vital signs and weight were summarized for each study visit, and the groups were compared with respect to mean change using the 2-sample t test. Physical examination data were listed, and any new physical findings were summarized.

Consult your doctor to determine when starting or stopping this medication is safe. Although rare, a severe allergic reaction to this drug can occur. You may experience drowsiness, dizziness, dry mouth, constipation, or fatigue while using this medication.

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Other treatments can help with spasticity as well, including physical therapy and Botox® injections. Although antispastics and antispasmodics are both types https://flexeril.live of skeletal muscle relaxants, they have specific and different uses. In addition, some of these medications treat conditions not related to muscle function.

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Consequently, achieving high nighttime and low daytime blood levels of CBP requires bedtime dosing of immediate-release CBP formulations. Interactions between medications can influence their effectiveness or increase the risk of experiencing severe side effects. Please be aware that this document does not encompass all conceivable drug interactions.

Cyclobenzaprine Dual Diagnosis Treatment

Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body. Sleepiness is a common side effect of cyclobenzaprine and other muscle relaxers. This can last for 4 to 6 hours with immediate-release tablets. During this time, it’s recommended to avoid drinking alcohol, operating machinery, driving, or any high performing tasks.